Genetics of Bleeding Disorders

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Genetics of Bleeding Disorders

Genetic bleeding disorders form an important presentation among various genetic disorders occurring in children. A prevalence of 6 per 100,000 population has been reported in India. Bleeding disorders constitute a heterogenous group of disorders with varying clinical presentations. The common bleeding disorders are Hemophilia A and B, von Willebrand disease, and inherited thrombocytopenias. In ...

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Bleeding Disorders

Bleeding disorders are usually taken to mean coagulopathies with reduced clotting of the blood but also encompass disorders characterised by abnormal platelet function or blood vessel walls that result in increased bleeding. Bleeding disorders may result from faults at many different levels in the coagulation process. They can range from severe and life-threatening conditions, such as haemophil...

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Pathophysiology of bleeding disorders.

Bleeding disorders and thromboembolic diseases represent abnormalities of the hemostatic mechanism. As this mechanism is basically a defense device against the loss of blood from the vascular system, any serious breakdown can bring about life-threatening hemorrhages. The author describes the inherent problems involved in these cases; and since many of the recognized congenital and acquired blee...

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a review on genetics of sleep disorders

ône-third of population deal with sleep disorders which might be due to social, economic or medical problems. studies on twins have indicated the role of genetic factors in these disorders. monozygotic twins have a very similar hypnogram. â higher prevalence of some sleep disorders is reported in relatives of the patients with these disorders. genes also affect sleep disorders as well as some o...

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Genetics of pigmentary disorders.

The genetic and molecular bases of various types of congenital pigmentary disorders have been classified in the past 10 years, as follows: (1) disorders of melanoblast migration in the embryo from the neural crest to the skin: piebaldism; Waardenburg syndrome 1-4 (WS1-WS4); dyschromatosis symmetrica hereditaria. (2) Disorders of melanosome formation in the melanocyte: Hermansky-Pudlak syndrome ...

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ژورنال

عنوان ژورنال: INTERNATIONAL JOURNAL OF HUMAN GENETICS

سال: 2006

ISSN: 0972-3757,2456-6330

DOI: 10.31901/24566330.2006/06.01.03